Basic Information
| LncRNA/CircRNA Name | LINC00968 |
| Synonyms | NA |
| Region | GRCh38_8:56496246-56559823 |
| Ensemble | ENSG00000246430 |
| Refseq | NR_038236 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot, in vitro knockdown etc. |
| Sample | cell line (BEAS-2B, A549, H1299, SPCA1 and H358), LUAD tumor tissues |
| Expression Pattern | up-regulated |
| Function Description | LINC00968 was significantly increased in LUAD tissues, LUSC tissues and NSCLC cells compared to their corresponding controls. Inhibition of Additionally, downregulation of LINC00968 induced apoptosis capacity of A549 cell. Apoptosis-related proteins BCL-2 were decreased and BAX was increased by knockdown of LINC00968, respectively. Meanwhile we observed that Wnt signaling pathway was involved in the LINC00968-induced NSCLC progression. Finally, in vivo tumor xenografts were established using A549 cells to detect the function of LINC00968 in NSCLC tumorigenesis. Silencing LINC00968 greatly inhibited NSCLC tumor progression, which was consistent with the in vitro tests. In conclusion, we have uncovered that LINC00968 could be regarded as a novel prognostic biomarker and therapeutic target in NSCLC diagnosis and treatment. |
| Pubmed ID | 28926089 |
| Year | 2017 |
| Title | Long non-coding RNA LINC00968 acts as oncogene in NSCLC by activating the Wnt signaling pathway. |
External Links
| Links for LINC00968 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |