Basic Information
| LncRNA/CircRNA Name | LINC00968 |
| Synonyms | NA |
| Region | GRCh38_8:56496246-56559823 |
| Ensemble | ENSG00000246430 |
| Refseq | NR_038236 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, Western blot, Luciferase reporter assay, RIP |
| Sample | Immortalized human mammary epithelial cell line MCF-10A and BC cell lines (BT-20, MCF-7, MDA-MB-231 and T-47D), BC tissues and adjacent normal tissues |
| Expression Pattern | down-regulated |
| Function Description | LINC00968 expression reduced while hsa-miR-423-5p increased in BC tissues relative to adjacent normal tissues. Overexpression of LINC00968 was observed to inhibit BC cell proliferation, migration and tube formation abilities in vitro as well as tumor growth in vivo through inhibition of hsa-miR-423-5p. And hsa-miR-423-5p mediated BC cellular functions and tumor growth through down-regulating PROX1. LINC00968 was identified as a competing endogenous RNA to upregulate PROX1 by downregulating hsa-miR-423-5p. More importantly, it was found that LINC00968 increased PROX1 expression in vivo in a concentration-dependent manner. |
| Pubmed ID | 31213129 |
| Year | 2019 |
| Title | Long non-coding RNA LINC00968 reduces cell proliferation and migration and angiogenesis in breast cancer through up-regulation of PROX1 by reducing hsa-miR-423-5p |
External Links
| Links for LINC00968 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |