Basic Information
| LncRNA/CircRNA Name | LINC00968 |
| Synonyms | NA |
| Region | GRCh38_8:56496246-56559823 |
| Ensemble | ENSG00000246430 |
| Refseq | NR_038236 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, in vitro knockdown |
| Sample | osteosarcoma cell lines(U2OS, MG63, Saos-2, SW1353, 143-B and hFOB) |
| Expression Pattern | up-regulated |
| Function Description | We observed that LINC00968 was dramatically elevated in osteosarcoma cells. Silence of LINC00968 inhibited osteosarcoma cell growth and proliferation in vitro. Reversely, overexpression of LINC00968 promoted osteosarcoma cell survival and cell colony formation ability in Saos-2 and 143-B cells. In addition, LINC00968 was able to induce osteosarcoma cell migration and invasion through up-regulating MMP-2 and MMP-9 protein levels. Here, in our study, we found that PI3K/AKT/mTOR pathway was involved in osteosarcoma progression. Knockdown of LINC00968 inactivated PI3K/AKT/mTOR signaling pathway in vitro. Subsequently, in vivo tumor xenografts were established using 143-B cells to investigate whether LINC00968 can induce osteosarcoma development in vivo. |
| Pubmed ID | 29904919 |
| Year | 2018 |
| Title | LINC00968 Functions as an Oncogene in Osteosarcoma by Activating the PI3K/AKT/mTOR Signaling |
External Links
| Links for LINC00968 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |