Basic Information
| LncRNA/CircRNA Name | LINC00963 |
| Synonyms | NA |
| Region | GRCh38_9:129483451-129513686 |
| Ensemble | ENSG00000204054 |
| Refseq | NR_038955 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, Luciferase reporter assay etc |
| Sample | glioma tissues and matched adjacent nontumor tissues,cell lines (U87, U251, SHG44, A172) |
| Expression Pattern | up-regulated |
| Function Description | Mechanistically, the results of luciferase activity and RNA pulldown assays validated that LINC00963 could act as a molecular sponge of miR-506. Reciprocal repression was found between LINC00963 and miR-506. In addition, BCAT1 was identified as a target of miR-506, and both the mRNA and protein levels of BCAT1 were reduced by miR-506. |
| Pubmed ID | 32273770 |
| Year | 2020 |
| Title | LINC00963 Confers Oncogenic Properties in Glioma by Regulating the miR-506/BCAT1 Axis |
External Links
| Links for LINC00963 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |