Basic Information
| LncRNA/CircRNA Name | LINC00961 |
| Synonyms | SPAAR, LINC00961, SPAR??lin-RECK-3 |
| Region | GRCh38_9:35909483-35937153 |
| Ensemble | ENSG00000235387 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | PCR, Western blot analysis |
| Sample | Human NSCLC cell lines (A549 and H226) lung cancer tissues( LUAD tumor and LUSC tumor tissues) compared with the peri??umor tissues and the healthy normal controls |
| Expression Pattern | down-regulated |
| Function Description | it was significantly reduced in human non-small cell lung cancer (NSCLC) tissues. upregulation of LINC00961 repressed proliferating cell nuclear antigen expression and increased Bax expression, indicating that it acts as an important pro-apoptosis gene. Conversely, inhibition of LINC00961 induced proliferating cell nuclear antigen expression and restrained Bax protein levels. |
| Pubmed ID | 30010215 |
| Year | 2018 |
| Title | Long noncoding RNA LINC00961 inhibits cell proliferation and induces cell apoptosis in human non-small cell lung cancer. |
External Links
| Links for LINC00961 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |