Basic Information
| LncRNA/CircRNA Name | LINC00961 |
| Synonyms | SPAAR, LINC00961, SPAR??lin-RECK-3 |
| Region | GRCh38_9:35909483-35937153 |
| Ensemble | ENSG00000235387 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot |
| Sample | NSCLC tissue, cell lines (SPC-A1, A549, PC9, NCI-H1299, NCI-H1975, SK-MES-1, 16HBE) |
| Expression Pattern | down-regulated |
| Function Description | Decreased LINC00961 was associated with NSCLC patients advanced clinical stage, lymph node metastasis, and shorter survival time. LSD1 could directly bind to LINC00961 promoter regions and epigenetically repress its transcription in NSCLC cells.Ectopic overexpression of LINC00961 inhibits NSCLC cell migration,invasion in vitro and metastasis in vivo. LINC00961 could act as a tumor suppressor partially via affecting B-catenin expression. Collectively, decreased LINC00961 might play a key role in NSCLC progression, and may serve as a novel prognostic marker in human NSCLC. |
| Pubmed ID | 29156520 |
| Year | 2017 |
| Title | Long noncoding RNA LINC00961 inhibits cell invasion and metastasis in human non-small cell lung cancer. |
External Links
| Links for LINC00961 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |