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Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis	apoptosis	Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	non small cell lung cancer
ICD-0-3	C34
Methods	Microarray, qPCR, Western blot
Sample	NSCLC tissues, cell lines (H226 and A549)
Expression Pattern	down-regulated
Function Description	We recognized lncRNA LINC00961, and we observed that it was significantly reduced in human non-small cell lung cancer (NSCLC) tissues. Furthermore, it was shown that LINC00961 overexpression greatly inhibited lung cancer cell proliferation, whereas downregulated LINC00961 induced cell proliferation. We found that inhibition ofLINC00961 was able to induce NSCLC cell growth,whereas upregulation of LINC00961 exhibited a reversephenomenon. In addition, further experiments showed that restoration of LINC00961 could dramatically increase apoptotic ratios of NSCLC H226 and A549 cells, and knockdown of LINC00961 exhibited an opposite effect. Moreover, Western blot analysis showed that upregulation of LINC00961 repressed proliferating cell nuclear antigen expression and increased Bax expression, indicating that it acts as an important pro-apoptosis gene. Conversely, inhibition of LINC00961 induced proliferating cell nuclear antigen expression and restrained Bax protein levels.
Pubmed ID	30010215
Year	2018
Title	Long Noncoding RNA LINC00961 Inhibits Cell Proliferation and Induces Cell Apoptosis in Human Non-Small Cell Lung Cancer

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