Basic Information
| LncRNA/CircRNA Name | LINC00959 |
| Synonyms | NA |
| Region | GRCh38_10:130063896-130110817 |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Western blot, RNAi etc. |
| Sample | human colon cancer cell lines (HCT116, SW480) |
| Expression Pattern | down-regulated |
| Function Description | In vitro, LINC00959 knockdown enhanced colon cancer cell proliferation, invasion, and migration; upregulated N-cadherin and vimentin; and downregulated E-cadherin and Caspase-3. LINC00959 overexpression produced the opposite effects. These data suggest that LINC00959 inhibits tumor cell invasion and migration by suppressing epithelial-mesenchymal transition and promotes apoptosis through Caspase-3. LINC00959 may be a tumor suppressor and useful prognostic biomarker in CRC.Survival analysis for LINC00959 expression in 116 CRC patients from the OncoLnc database. (P=0.0218) |
| Pubmed ID | 29228592 |
| Year | 2017 |
| Title | Long non-coding RNA LINC00959 predicts colorectal cancer patient prognosis and inhibits tumor progression. |
External Links
| Links for LINC00959 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |