Basic Information
| LncRNA/CircRNA Name | ABHD11-AS1 |
| Synonyms | NA |
| Region | NA |
| Ensemble | ENSG00000225969 |
| Refseq | NR_026690 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | papillary thyroid cancer |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown, RIP, etc. |
| Sample | papillary thyroid cancer tissues, BCPAP (PTC cell line) ,Nthy-ori 3-1 (the normal cell line) ,K1 (PTC cell line) ,BHP5-16 and BHP2-7 (PTC cell lines) |
| Expression Pattern | up-regulated |
| Function Description | High expression of ABHD11 AS1 predicted poor prognosis for patients with PTC and promoted cell proliferation and metastasis in vitro and in vivo. ABHD11 AS1 was activated by the transcription factor STAT3. ABHD11 AS1 positively regulated PI3K/AKT signalling pathway. ABHD11 AS1 acted as a competitive endogenous (ce) RNA to upregulate STAT3 by sponging miR 1301 3p. |
| Pubmed ID | 30657221 |
| Year | 2019 |
| Title | STAT3-induced upregulation of lncRNA ABHD11-AS1 promotes tumour progression in papillary thyroid carcinoma by regulating miR-1301-3p/STAT3 axis and PI3K/AKT signalling pathway |
External Links
| Links for ABHD11-AS1 | GenBank HGNC NONCODE |
| Links for papillary thyroid cancer | OMIM COSMIC |