Basic Information
| LncRNA/CircRNA Name | LINC00958 |
| Synonyms | NA |
| Region | GRCh38_11:12961842-12989548 |
| Ensemble | ENSG00000251381 |
| Refseq | NR_038904 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | bladder cancer |
| ICD-0-3 | C67 |
| Methods | Microarray, qPCR, Northern blot, RNA pull-down assay etc. |
| Sample | bladder cancer tissues, cell lines (RT4, HT1376, HT1197, T24, J82, UMUC3 etc.) |
| Expression Pattern | differential expression |
| Function Description | Silencing of LINC00958 or LINC01296 in vitro reduced both cell viability and migration. Knock-down of LINC00958 also affected invasion and resistance to anoikis. These cellular effects could be linked to direct/indirect regulation of protein coding mRNAs involved in cell death/survival, proliferation and cellular movement. Finally, we showed that LINC00958 binds proteins involved in regulation and initiation of translation and in post-transcriptional modification of RNA, including Metadherin, which has previously been associated with BC. |
| Pubmed ID | 28341852 |
| Year | 2017 |
| Title | Profiling of long non-coding RNAs identifies LINC00958 and LINC01296 as candidate oncogenes in bladder cancer. |
External Links
| Links for LINC00958 | GenBank HGNC NONCODE |
| Links for bladder cancer | OMIM COSMIC |