Basic Information
| LncRNA/CircRNA Name | LINC00958 |
| Synonyms | NA |
| Region | GRCh38_11:12961842-12989548 |
| Ensemble | ENSG00000251381 |
| Refseq | NR_038904 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot etc. |
| Sample | glioma tissues, cell lines (SHG44, U87, U251 and A172) |
| Expression Pattern | up-regulated |
| Function Description | LINC00958 was significantly upregulated in glioma tissues and cell lines compared with that of adjacent normal brain tissues and normal human astrocytes. Moreover, the ectopic overexpression of LINC00958 was correlated with poor prognosis of glioma patients. Loss-of-function experiments indicated that LINC00958 knockdown suppressed glioma cell proliferation, invasion, and induced cycle arrest at G0/G1 phase in vitro, and inhibited tumor growth in vivo. Bioinformatics programs and luciferase reporter assay revealed that miR-203 shared complementary binding sites with both 3'-untranslated region of LINC00958 and CDK2. |
| Pubmed ID | 29570358 |
| Year | 2018 |
| Title | Long Noncoding RNA LINC00958 Accelerates Gliomagenesis Through Regulating miR-203/CDK2. |
External Links
| Links for LINC00958 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |