Basic Information
| LncRNA/CircRNA Name | LINC00958 |
| Synonyms | NA |
| Region | GRCh38_11:12961842-12989548 |
| Ensemble | ENSG00000251381 |
| Refseq | NR_038904 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | oral squamous cell carcinoma |
| ICD-0-3 | C06.9 |
| Methods | qRT-PCR , Luciferase reporter assay , Western blot , RIP , in vitro knockdown etc. |
| Sample | OSCC tissues and the paired adjacent normal tissues,OSCC cell lines (SCC15, TSCCA, HSU3, and Fadu) and primary normal human oral keratinocytes (NHOK) cell line. |
| Expression Pattern | up-regulated |
| Function Description | OSCC clinical samples that LINC00958 presented high expression and predicted poor prognosis.Also, LINC00958 was elevated in OSCC cells.LINC00958 facilitated cell growth, retarded apoptosis, accelerated migration, and epithelial-to-mesenchymal transition (EMT) in OSCC.LINC00958 promoted OSCC progression through miR-627-5p/YBX2 axis. |
| Pubmed ID | 31161900 |
| Year | 2019 |
| Title | LINC00958 Regulated miR-627-5p/YBX2 Axis to Facilitate Cell Proliferation and Migration in Oral Squamous Cell Carcinoma |
External Links
| Links for LINC00958 | GenBank HGNC NONCODE |
| Links for oral squamous cell carcinoma | OMIM COSMIC |