Basic Information
| LncRNA/CircRNA Name | LINC00958 |
| Synonyms | NA |
| Region | GRCh38_11:12961842-12989548 |
| Ensemble | ENSG00000251381 |
| Refseq | NR_038904 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | Luciferase reporter assay , Western blot etc. |
| Sample | radio-sensitive cases and radio-resistant cases tissues ,Hela cells |
| Expression Pattern | up-regulated |
| Function Description | High expression of LINC00958 was associated with lower sensitivity to radiotherapy in cervical cancer.Moreover, cervical cancer patients with higher LINC00958 expression exhibited a shorter overall survival.In addition, LINC00958 could regulate the expression of RRM2 by competing for miR-5095.A combination of radiotherapy with LINC00958 silencing, RRM2 downregulation or miR-5095 overexpression was found to inhibit cervical cancer cell proliferation and tumor growth, while promoting cell apoptosis both in vitro and in vivo. |
| Pubmed ID | 31169309 |
| Year | 2019 |
| Title | Long Noncoding RNA LINC00958 Regulates Cell Sensitivity to Radiotherapy Through RRM2 by Binding to microRNA-5095 in Cervical Cancer |
External Links
| Links for LINC00958 | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |