Basic Information
| LncRNA/CircRNA Name | LINC00957 |
| Synonyms | NA |
| Region | GRCh38_7:44039171-44042306 |
| Ensemble | ENSG00000235314 |
| Refseq | NR_015401 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | 5-FU | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Western blot, etc. |
| Sample | CRC tissues, CRC cell lines (HCT8, SW480, SW620, LOVO, HCT116) and normal human colon epithelial cells NCM460 |
| Expression Pattern | up-regulated |
| Function Description | LINC00957 was significantly higher expression in CRC. In addition, the LINC00957 expression was associated with TNM stage and chemotherapy outcome, but age, gender, tumor size, histological grade, primary tumor location. CRC patients with high LINC00957 expression level showed poor overall survival (P = 0.002). Multivariate survival analysis indicated that LINC00957 was a prognostic factor for CRC patients (P = 0.010). Mechanically, inhibition of LINC00957 expression reversed 5-FU resistance by down-regulating P-gP. |
| Pubmed ID | 31497531 |
| Year | 2019 |
| Title | LINC00957 Acted as Prognostic Marker Was Associated With Fluorouracil Resistance in Human Colorectal Cancer |
External Links
| Links for LINC00957 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |