Basic Information
| LncRNA/CircRNA Name | LINC00899 |
| Synonyms | NA |
| Region | GRCh38_22:46039907-46044853 |
| Ensemble | ENSG00000231711 |
| Refseq | NR_027036 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | acute myeloid leukemia |
| ICD-0-3 | NA |
| Methods | qRT-PCR, Western blot |
| Sample | AML cell lines( THP-1, HL-60, KG-1, ARH-77 and NOMO-1),blood |
| Expression Pattern | up-regulated |
| Function Description | High expression of LINC00899 in AML cells could promote cell proliferation and inhibit cell apoptosis, and facilitate the progression of AML consequently both in vitro and in vivo. LINC00899 modulated AML cell proliferation and apoptosis via regulating YY1 |
| Pubmed ID | 32157707 |
| Year | 2020 |
| Title | LncRNA LINC00899 promotes progression of acute myeloid leukaemia by modulating miR-744-3p/YY1 signalling |
External Links
| Links for LINC00899 | GenBank HGNC NONCODE |
| Links for acute myeloid leukemia | OMIM COSMIC |