Basic Information
| LncRNA/CircRNA Name | LINC0086 |
| Synonyms | LED, LINC0086, LINC00086, NCRNA00086,SMIM10L2A |
| Region | GRCh38_X:135421943-135428074 |
| Ensemble | ENSG00000178947 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | nasopharyngeal cancer |
| ICD-0-3 | C11 |
| Methods | qPCR, Cell transfection, Luciferase reporter assay, Flow cytometry assay, CCK-8 assay etc. |
| Sample | serum, NPC tissues, cell lines (C666-1 and HK-1) |
| Expression Pattern | down-regulated |
| Function Description | LINC0086 decreased in NPC patient serum samples and tissues.Upregulation of LINC0086 inhibited cancer cell proliferation and promoted apoptosis. In addition, Upregulation of LINC0086 dramatically decreased the expression of miR-214 in C666-1 and HK-1 cells.We also validated that both miR-214 and LINC0086 presented in the RISC complex, demonstrating that LINC0086 could decrease miR-214 expression by directly interacting with miR-214. Furthermore, the suppressive effects of LINC0086 on NPC cell growth were reversed by overexpression miR-214 expression in vitro and in vivo. |
| Pubmed ID | 28245169 |
| Year | 2017 |
| Title | Long Non-Coding RNA LINC0086 Functions as a Tumor Suppressor in Nasopharyngeal Carcinoma By Targeting miR-214. |
External Links
| Links for LINC0086 | GenBank HGNC NONCODE |
| Links for nasopharyngeal cancer | OMIM COSMIC |