Basic Information
| LncRNA/CircRNA Name | LINC00858 |
| Synonyms | LINC00858 |
| Region | GRCh38_10:84279980-84294659 |
| Ensemble | ENSG00000229404 |
| Refseq | NR_038220 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, RNAi, Western blot, Luciferase reporter assay, RNA pull-down assay, CCK-8 assay etc. |
| Sample | NSCLC tissues, cell lines (A549, SK-MES-1, H1299, 95D, H460, H520, H1975, H157, SK-LU-1, and SPC-A-1) |
| Expression Pattern | up-regulated |
| Function Description | LINC00858 levels were remarkably higher in NSCLC tissues and cell lines. Ectopic expression of LINC00858 in NSCLC cells promoted cell proliferation and induced cell migration and invasion. Moreover, LINC00858 functioned as a competitive endogenous RNA (ceRNA),effectively becoming sponge for miR-422a and thereby modulating the expression of kallikrein-related peptidase 4 (KLK4). In NSCLC patients, high expression of LINC00858 closely correlated with tumor progression. |
| Pubmed ID | 28177876 |
| Year | 2017 |
| Title | Long intergenic non-protein coding RNA 00858 functions as a competing endogenous RNA for miR-422a to facilitate the cell growth in non-small cell lung cancer. |
External Links
| Links for LINC00858 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |