Basic Information
| LncRNA/CircRNA Name | LINC00858 |
| Synonyms | NA |
| Region | GRCh38_10:84279980-84294659 |
| Ensemble | ENSG00000229404 |
| Refseq | NR_038220 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung cancer |
| ICD-0-3 | C34 |
| Methods | RT-PCR , Luciferase reporter assay , Western blot etc. |
| Sample | lung cancer tissues , normal lung tissues ,human lung cancer cell lines (A549 and H1299, H226, H446) ,human bronchial epithelial cells BEAS-2B |
| Expression Pattern | up-regulated |
| Function Description | Over-expression of linc00858 significantly promoted cell proliferation, invasion.linc00858 facilitated the EMT process.linc00858 can bind with miR-3182 directly. Linc00858 can negatively regulate the expression of miR-3182.MMP2 was the direct target of miR-3182.linc00858 functioned through miR-3182/MMP2 axis. |
| Pubmed ID | 31131637 |
| Year | 2019 |
| Title | The Long Noncoding RNA linc00858 Promotes Progress of Lung Cancer Through miR-3182/MMP2 Axis |
External Links
| Links for LINC00858 | GenBank HGNC NONCODE |
| Links for lung cancer | OMIM COSMIC |