Basic Information
| LncRNA/CircRNA Name | LINC00858 |
| Synonyms | NA |
| Region | GRCh38_10:84279980-84294659 |
| Ensemble | ENSG00000229404 |
| Refseq | NR_038220 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colon cancer |
| ICD-0-3 | C18 |
| Methods | RT-qPCR, Western blot analysis, RIP, Dual luciferase reporter assay |
| Sample | Colon cancer tissues,colon cancer cell lines, SW480, LoVo, HCT116, SW620, HT29, SW1116 andHCT-8, and one control human normal colon cell line, NCM460 |
| Expression Pattern | up-regulated |
| Function Description | LINC00858 was highly expressed in primary colon cancer tissues and colon cancer cell lines, and was mainly located in the nucleus. High LINC00858 expression was found to correlate with a poor differentiation, advanced TNM stages and lymph node metastasis. Exogenous overexpression of LINC00858 promoted cell proliferation, invasion and migration of colon cancer cells, and facilitated angiogenesis and tumor growth. In addition, we found that LINC00858 can bind to and upregulate the nuclear transcription factor HNF4?, leading to WNK2 expression downregulation. |
| Pubmed ID | 31884577 |
| Year | 2020 |
| Title | Long Non-Coding RNA LINC00858 Exerts a Tumor-Promoting Role in Colon Cancer via HNF4? and WNK2 Regulation |
External Links
| Links for LINC00858 | GenBank HGNC NONCODE |
| Links for colon cancer | OMIM COSMIC |