Basic Information
| LncRNA/CircRNA Name | LINC00858 |
| Synonyms | NA |
| Region | GRCh38_10:84279980-84294659 |
| Ensemble | ENSG00000229404 |
| Refseq | NR_038220 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown, RIP |
| Sample | osteosarcoma tissues, cell lines (MG-63, U2OS, 143 B, Saos-2) |
| Expression Pattern | up-regulated |
| Function Description | LINC00858 expression was significantly upregulated in both osteosarcoma tissues and cell lines. Mechanism assays presented that LINC00858 silencing significantly repressed osteosarcoma cells' proliferation and invasion in vitro, and inhibited the tumor growth in vivo. In further experiments, LINC00858 was identified to sponge miR-139 to form RNA-induced silencing complex (RISC) using luciferase reporter assay and RNA immunoprecipitation (RIP). Besides, CDK14 was validated to be the target protein the miR-139. Rescue experiments confirmed the role of LINC00858/miR-139/CDK14 pathway on osteosarcoma cells' phenotype. |
| Pubmed ID | 29944887 |
| Year | 2018 |
| Title | Long Noncoding RNA LINC00858 Promotes Osteosarcoma Through Regulating miR-139-CDK14 Axis |
External Links
| Links for LINC00858 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |