Basic Information
| LncRNA/CircRNA Name | LINC00857 |
| Synonyms | LINC00857 |
| Region | GRCh38_10:80207710-80219657 |
| Ensemble | ENSG00000237523 |
| Refseq | NR_038464 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qRT-PCR, Western blot analysis |
| Sample | GC cell lines (AGS, BGC-823, MKN-45 and SGC-7901) and a gastric epithelial cell line (GES-1) GC tissues and adjacent non-tumor tissues |
| Expression Pattern | up-regulated |
| Function Description | LINC00857 was increased in GC tissues compared with adjacent non-tumor tissues.LINC00857 knockdown induced by specific small interfering RNAs significantly inhibited GC cell proliferation in vitro. the results indicated that LINC00857 knockdown suppressed GC cell proliferation through deregulating the cell cycle, resulting in the downregulation of cyclin D1 and cyclin E1. |
| Pubmed ID | 30008909 |
| Year | 2018 |
| Title | Long non-coding RNA LINC00857 promotes gastric cancer cell proliferation and predicts poor patient survival. |
External Links
| Links for LINC00857 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |