Basic Information
| LncRNA/CircRNA Name | LINC00857 |
| Synonyms | LINC00857 |
| Region | GRCh38_10:80207710-80219657 |
| Ensemble | ENSG00000237523 |
| Refseq | NR_038464 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung cancer |
| ICD-0-3 | C34 |
| Methods | Microarray, qPCR, RNAi etc. |
| Sample | lung cancer tissues, cell lines (H1299, H838 and SK-LU-1) |
| Expression Pattern | down-regulated |
| Function Description | LINC00857, a top deregulated lncRNAs, was overexpressed in tumors and significantly associated with poor survival in LUAD. knockdown of LINC00857 with siRNAs decreased tumor cell proliferation, colony formation, migration and invasion in vitro, as well as tumor growth in vivo. Overexpression of LINC00857 increased cancer cell proliferation, colony formation and invasion. Mechanistic analyses indicated that LINC00857 mediates tumor progression via cell cycle regulation. |
| Pubmed ID | 26862852 |
| Year | 2016 |
| Title | Non-coding RNA LINC00857 is predictive of poor patient survival and promotes tumor progression via cell cycle regulation in lung cancer |
External Links
| Links for LINC00857 | GenBank HGNC NONCODE |
| Links for lung cancer | OMIM COSMIC |