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Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis	apoptosis	Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	hepatocellular carcinoma
ICD-0-3	C22.0
Methods	qPCR, Luciferase reporter assay, in vitro knockdown, etc.
Sample	Hep-3B, HepG2, MHCC-97H, SNU-449, Huh-7, and LO2 cells
Expression Pattern	up-regulated
Function Description	LINC00857 was overexpressed in HCC cell lines (Huh7, Hep3B, HepG2, MHCC 97H, and SNU449). Knockdown of LINC00857 significantly repressed Hep 3B and SNU449 cell proliferation and inhibited the HCC cell colony formation. In addition, cell apoptosis was induced by the silence of LINC00857 and cell cycle progression was blocked in G1 phase. Besides these, downregulation of LINC00857 was able to restrain HCC cell migration and invasion capacity via enhancing epithelial mesenchymal transition (EMT) process. As displayed, E cadherin protein expression was increased by LINC00857 silence, while N cadherin protein level was repressed by LV shLINC00857 in HCC cells. Finally, the in vivo assays were used and the data indicated that LINC00857 could also obviously suppress the HCC tumor growth in vivo.
Pubmed ID	30506763
Year	2018
Title	LINC00857 contributes to hepatocellular carcinoma malignancy via enhancing epithelial-mesenchymal transition

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