Basic Information
| LncRNA/CircRNA Name | LINC00857 |
| Synonyms | NA |
| Region | GRCh38_10:80207710-80219657 |
| Ensemble | ENSG00000237523 |
| Refseq | NR_038464 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | esophageal adenocarcinoma |
| ICD-0-3 | C15 |
| Methods | qRT-PCR , Western blot , in vitro knockdown etc. |
| Sample | esophageal adenocarcinoma tissues and paired non-tumor tissues ,EAC cell lines(OE19, OE33 and FLO1) |
| Expression Pattern | up-regulated |
| Function Description | We found that the cell proliferation, colony formation, invasion and migration were decreased after LINC00857 knockdown in EAC cell lines. We also found that knockdown LINC00857 could induce apoptosis. Mechanistically, we found that the MET, STAT3, c-Myc and p-CREB proteins were decreased after LINC00857 knockdown. Our study suggests that LINC00857 may play an important oncogenic role in EAC via STAT3 and MET signaling. |
| Pubmed ID | 31085800 |
| Year | 2019 |
| Title | LINC00857?Knockdown Inhibits Cell Proliferation and Induces Apoptosis via Involving STAT3 and MET Oncogenic Proteins in Esophageal Adenocarcinoma |
External Links
| Links for LINC00857 | GenBank HGNC NONCODE |
| Links for esophageal adenocarcinoma | OMIM COSMIC |