Basic Information
| LncRNA/CircRNA Name | LINC00857 |
| Synonyms | NA |
| Region | GRCh38_10:80207710-80219657 |
| Ensemble | ENSG00000237523 |
| Refseq | NR_038464 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung adenocarcinoma |
| ICD-0-3 | C34 |
| Methods | qRT-PCR, Dual luciferase assay, Western blot analysis |
| Sample | LUAD tissues,LUAD cell lines, H1229 and H838, and human pulmonary epithelial cells, BEAS-2B |
| Expression Pattern | up-regulated |
| Function Description | a dramatical upregulation of LINC00857 compared with the adjacent normal lung tissues and BEAS-2B cell line, respectively.LINC00857 knockdown led to the cell proliferation and glycolysis was repressed, while the apoptosis was elevated in LUAD cell lines.lncRNA LINC00857 regulated the cell proliferation, glycolysis and apoptosis of LUAD cells mainly through targeting the miR-1179/SPAG5 axis. |
| Pubmed ID | 31667785 |
| Year | 2020 |
| Title | LncRNA LINC00857 Regulates Lung Adenocarcinoma Progression, Apoptosis and Glycolysis by Targeting miR-1179/SPAG5 Axis |
External Links
| Links for LINC00857 | GenBank HGNC NONCODE |
| Links for lung adenocarcinoma | OMIM COSMIC |