Basic Information
| LncRNA/CircRNA Name | LINC00707 |
| Synonyms | NA |
| Region | GRCh38_10:6779598-6842906 |
| Ensemble | ENSG00000238266 |
| Refseq | NR_038291 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | docetaxel | |
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung adenocarcinoma |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot, RNAi |
| Sample | lung adenocarcinoma tissues, cell lines(SPCA1, A549, H1299, H1975,16HBE) |
| Expression Pattern | up-regulated |
| Function Description | The expression level of LINC00707 was clearly upregulated in LAD tissues compared to that in corresponding normal tissues.Its overexpression was related to advanced TNM stage, larger tumor size, lymphatic metastasis, and poor prognosis.LINC00707 knockdown repressed LAD cell proliferation both in vitro and in vivo. This process may involve the inducing of G1 arrest and apoptosis.cell migration was impaired after LINC00707 inhibition.Cdc42 is an important target gene involved in the carcinogenesis of LINC00707.LINC00707 is a noncoding oncogene that exerts important regulatory functions in LAD, suggesting its potential as a biomarker in the prognosis and treatment of LAD.patients expressing higher levels of LINC00707 had poorer disease-free survival and overall survival. |
| Pubmed ID | 29482190 |
| Year | 2018 |
| Title | The Long Intergenic Noncoding RNA 00707 Promotes Lung Adenocarcinoma Cell Proliferation and Migration by Regulating Cdc42. |
External Links
| Links for LINC00707 | GenBank HGNC NONCODE |
| Links for lung adenocarcinoma | OMIM COSMIC |