Basic Information
| LncRNA/CircRNA Name | LINC00707 |
| Synonyms | NA |
| Region | GRCh38_10:6779598-6842906 |
| Ensemble | ENSG00000238266 |
| Refseq | NR_038291 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qRT-PCR , Luciferase reporter assay , Western blot , in vitro knockdown etc. |
| Sample | tumor tissues and adjacent tissues ,human colorectal cell lines(SW620, SW620,SW480, HCT116) ,human colorectal normal epithelial cell line NCM460 |
| Expression Pattern | up-regulated |
| Function Description | LINC00707 was significantly over-expressed in CRC tissues and cell lines. Up-regulation of LINC00707 promoted cell proliferation, cell cycle progression, invasion, and migration of SW620 cells. Conversely, down-regulation of LINC00707 reduced cell growth and metastasis of HCT116 cells. MiR-206 was verified as a direct target of LINC00707, and its function was inhibited by LINC00707. FMNL2 was a target for miR-206 in CRC cells. Meanwhile, LINC00707 promoted tumor growth of CRC in vivo. |
| Pubmed ID | 31115001 |
| Year | 2019 |
| Title | LINC00707 Promotes Cell Proliferation and Invasion of Colorectal Cancer via miR-206/FMNL2 Axis |
External Links
| Links for LINC00707 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |