Basic Information
| LncRNA/CircRNA Name | LINC00707 |
| Synonyms | NA |
| Region | GRCh38_10:6779598-6842906 |
| Ensemble | ENSG00000238266 |
| Refseq | NR_038291 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | Cisplatin | |
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot, Luciferase reporter assay etc |
| Sample | cell lines(A549/DDP) |
| Expression Pattern | up-regulated |
| Function Description | LINC00707 expression was found to be significantly upregulated in DDP-resistant A549 cells (A549/DDP) cells when compared with that in parental A549 cells. LINC00707 knockdown reduced the IC50 value of DDP, enhanced apoptosis and inhibited Bcl-2, MRP1 and P-gp expression, while promoting Bax expression in A549/DDP cells. miR-145 expression was found to be significantly decreased in A549/DDP cells when compared with in A549 cells. LINC00707 directly interacted with miR-145 and negatively regulated its expression. |
| Pubmed ID | 31788103 |
| Year | 2019 |
| Title | Silencing long intergenic non-coding RNA 00707 enhances cisplatin sensitivity in cisplatin-resistant non-small-cell lung cancer cells by sponging miR-145 |
External Links
| Links for LINC00707 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |