Basic Information
| LncRNA/CircRNA Name | LINC00704 |
| Synonyms | MANCR |
| Region | GRCh38_10:4650185-4678154 |
| Ensemble | ENSG00000231298 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | thyroid cancer |
| ICD-0-3 | C73.9 |
| Methods | qPCR, Western blot, in vitro knockdown |
| Sample | thyroid cancer cell lines (BHT101 and BCPAP) |
| Expression Pattern | up-regulated |
| Function Description | LINC00704 is upregulated in thyroid cancer, and higher LINC00704 expression levels are associated with thyroid cancer patients shorter OS time. Downregulation of LINC00704 could significantly impair thyroid cancer cells proliferation, colony formation, inhibit cell-cycle progression and cell invasion, and induce cell apoptosis. The results of western blot showed that E-cadherin expression was significantly increased, whereas N-cadherin and ?-catenin expression was decreased in LINC00704 siRNA transfected BHT101 and BCPAP cells. These data indicate that LINC00704 might involve in thyroid cancer progression through regulating EMT and cell invasion. |
| Pubmed ID | 29923329 |
| Year | 2018 |
| Title | Identification of Differential Expressed lncRNAs in Human Thyroid Cancer by a Genome-Wide Analyses |
External Links
| Links for LINC00704 | GenBank HGNC NONCODE |
| Links for thyroid cancer | OMIM COSMIC |