Basic Information
| LncRNA/CircRNA Name | LINC00689 |
| Synonyms | NA |
| Region | GRCh38_7:159006522-159030195 |
| Ensemble | ENSG00000231419 |
| Refseq | NR_024394 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qRT-PCR , Luciferase reporter assay , in vitro knockdown , Western blot etc. |
| Sample | glioma tissues and matched adjacent nontumor tissues,Human glioma cell lines (U87 and U251), normal human astrocytes(NHA), human embryonic kidney 293 T (HEK293 T) cells |
| Expression Pattern | up-regulated |
| Function Description | Here,the expression of LINC00689 was up-regulated in glioma tissues and cell lines.Moreover, the high expression of LINC00689 was closely correlated with tumor size ?? cm, high tumor grade, low KPS scores and poor prognosis of glioma patients.LINC00689 knockdown markedly repressed the proliferation, migration, invasion and glycolysis of glioma cells. Additionally, silencing of LINC00689 significantly suppressed the growth of glioma cells in vivo.Mechanistically, LINC00689 functioned as a competing endogenous RNA (ceRNA) by directly interacting with miR-338-3p to promote pyruvate kinase M2 (PKM2) expression.Notably, we also revealed that restoration of PKM2 abolished the effects of LINC00689 silencing on glioma cell proliferation, migration, invasion and glycolysis. |
| Pubmed ID | 31181442 |
| Year | 2019 |
| Title | LncRNA LINC00689 Promotes the Growth, Metastasis and Glycolysis of Glioma Cells by Targeting miR-338-3p/PKM2 Axis |
External Links
| Links for LINC00689 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |