Basic Information
| LncRNA/CircRNA Name | LINC00675 |
| Synonyms | NORAD, LINC00657, ASHGA5P032173 |
| Region | GRCh38_20:36045622-36050960 |
| Ensemble | ENSG00000260032 |
| Refseq | NR_027451 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Western blot, Luciferase reporter assay etc. |
| Sample | colorectal cancer tissues, cell lines(HT29, SW620 and HCT116) |
| Expression Pattern | down-regulated |
| Function Description | the down-regulation of Linc00675 in both CRC cells and clinical CRC tissues.Expression of Linc00675 was also relatively low in metastatic tumors and advanced tumors.Further studies also showed that overexpression of Linc00675 inhibited the proliferation,invasion and migration of CRC cells.In addition,our data also revealed the negative regulation of miR-942 by Linc00675 and the relatively higher expression of miR-942 in clinical CRC tissues.More importantly, the inhibitory effect of Linc00675 on proliferation, invasion and migration of HCT116 cells was also significantly attenuated in the presence of miR-942 mimic, suggesting that down-regulation of miR-942 represented one of the mechanisms by which Linc00675 inhibited the proliferation and metastasis of CRC. |
| Pubmed ID | 29524886 |
| Year | 2018 |
| Title | Long non-coding RNA Linc00675 suppresses cell proliferation and metastasis in colorectal cancer via acting on miR-942 and Wnt/B-catenin signaling. |
External Links
| Links for LINC00675 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |