Basic Information
| LncRNA/CircRNA Name | LINC00675 |
| Synonyms | NORAD, LINC00657, ASHGA5P032173 |
| Region | GRCh38_20:36045622-36050960 |
| Ensemble | ENSG00000260032 |
| Refseq | NR_027451 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | qPCR, Western blot, other |
| Sample | Cervical cancer tissues and cell lines(C-33A, HeLa, and CaSki) |
| Expression Pattern | up-regulated |
| Function Description | Overexpression of LINC00675 promoted cervical cancer cell proliferation, invasion, and migration. In addition, overexpression of LINC00675 inhibited cell apoptosis, increased the protein level of Bcl-2, and decreased the protein level of Bax in cervical cancer cells. However, knockdown of LINC00675 played a contrasting role in cervical cancer cells. Overexpression of LINC00675 also increased the activity of Wnt/?-catenin signaling in cervical cancer cells, whereas knockdown of LINC00675 suppressed the activity of Wnt/?-catenin signaling. In addition, lithium chloride treatment attenuated the effects of LIC00675 knockdown on CaSki cell proliferation, invasion and migration. |
| Pubmed ID | 30372871 |
| Year | 2018 |
| Title | The lncRNA LINC00675 Regulates Cell Proliferation, Migration, and Invasion by Affecting Wnt/?-catenin Signaling in Cervical Cancer |
External Links
| Links for LINC00675 | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |