Basic Information
| LncRNA/CircRNA Name | LINC00673 |
| Synonyms | LINC00673, HI-LNC75, HILNC75, LUCAIR1, SLNCR, SLNCR1 |
| Region | GRCh38_17:72403322-72592804 |
| Ensemble | NA |
| Refseq | NR_036488 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | Microarray, qPCR, RNAi, Western blot, RIP, ChIP, Luciferase reporter assay, Cell proliferation assay etc. |
| Sample | gastric cancer tissues, cell lines (BGC823, SGC7901, MGC803, and AGS) |
| Expression Pattern | up-regulated |
| Function Description | LINC00673 is significantly upregulated in gastric cancer. Knockdown of LINC00673 inhibited cell proliferation and invasion and induced cell apoptosis. SP1 could bind directly to the LINC00673 promoter region and activate its transcription. Moreover, CADM4, KLF2, and LATS2 might be the underlying targets of LINC00673 in GC cells, and LINC00673 can interact with EZH2 and LSD1, thereby repressing KLF2 and LATS2 expression. |
| Pubmed ID | 28214253 |
| Year | 2017 |
| Title | Long Noncoding RNA LINC00673 Is Activated by SP1 and Exerts Oncogenic Properties by Interacting with LSD1 and EZH2 in Gastric Cancer. |
External Links
| Links for LINC00673 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |