Basic Information
| LncRNA/CircRNA Name | LINC00673 |
| Synonyms | LINC00673, HI-LNC75, HILNC75, LUCAIR1, SLNCR, SLNCR1 |
| Region | GRCh38_17:72403322-72592804 |
| Ensemble | NA |
| Refseq | NR_036488 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot etc. |
| Sample | cell lines (BEAS-2B, A549, H1975, H596, H520, H1650, H1703 and HEK-293) |
| Expression Pattern | up-regulated |
| Function Description | high linc00673 expression was associated with poor prognosis of NSCLC patients.Linc00673 acted as a ceRNA by sponging miR-150-5p and regulated ZEB1 expression indirectly. linc00673 modulated cell proliferation, migration, invasion and EMT by sponging miR-150-5p and regulating ZEB1 expression indirectly. the inhibition of linc00673 significantly attenuated the tumorigenesis ability of A549 cells in vivo. Linc00673 is associated with poor survival in NSCLC patients. |
| Pubmed ID | 28697764 |
| Year | 2017 |
| Title | Long non-coding RNA linc00673 regulated non-small cell lung cancer proliferation, migration, invasion and epithelial mesenchymal transition by sponging miR-150-5p. |
External Links
| Links for LINC00673 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |