Basic Information
| LncRNA/CircRNA Name | LINC00673 |
| Synonyms | LINC00673, HI-LNC75, HILNC75, LUCAIR1, SLNCR, SLNCR1 |
| Region | GRCh38_17:72403322-72592804 |
| Ensemble | NA |
| Refseq | NR_036488 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot, RIP etc. |
| Sample | gastric cancer cell lines (MKN45, AGS, MKN-28 ,Sgastric cancer-7901) |
| Expression Pattern | down-regulated |
| Function Description | RNA immunoprecipitation (RIP) and chromatin immunoprecipitation (ChIP) proved that LINC00673 suppressed KLF4 expression by interacting with EZH2 and DNMT1 in GC cells. Moreover, we confirmed that LINC00673 promoted cell proliferation and invasion by partly repressing KLF4 expression in GC. Taken together, these results indicated that LINC00673 may be a prognostic biomarker and therapeutic target for GC patients.Higher LINC00673 expression predicted poor disease-free survival (DFS) and overall survival (OS) in GC patients. |
| Pubmed ID | 29221147 |
| Year | 2017 |
| Title | Long noncoding RNA LINC00673 epigenetically suppresses KLF4 by interacting with EZH2 and DNMT1 in gastric cancer |
External Links
| Links for LINC00673 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |