Basic Information
| LncRNA/CircRNA Name | LINC00673 |
| Synonyms | NA |
| Region | GRCh38_1:29554-31109 |
| Ensemble | |
| Refseq | NR_036488 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, Western blot |
| Sample | breast cancer tissues, cell lines(MDA-MB-231, BT-549, MDA-MB-468, MCF-7, MCF-10A) |
| Expression Pattern | up-regulated |
| Function Description | We discovered that LINC00673 is significantly upregulated in breast cancer tissues compared to paired adjacent non-tumor tissues. Knocking down LINC00673 inhibited cell proliferation and metastasis. Western Blot showed us that LINC00673 could regulate epithelial-mesenchymal transition (EMT) and B7-H6 in protein level. these results indicated that LINC00673 played a significant role in the proliferation and apoptosis capacities of the breast cancer cell lines. |
| Pubmed ID | 30094100 |
| Year | 2018 |
| Title | Long Non-Coding RNA LINC00673 Promotes Breast Cancer Proliferation and Metastasis Through Regulating B7-H6 and Epithelial-Mesenchymal Transition. |
External Links
| Links for LINC00673 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |