Basic Information
| LncRNA/CircRNA Name | LINC00673 |
| Synonyms | NA |
| Region | GRCh38_1:29554-31109 |
| Ensemble | |
| Refseq | NR_036488 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | thyroid cancer |
| ICD-0-3 | C73.9 |
| Methods | qPCR, Western blot |
| Sample | thyroid carcinoma tissues, cell lines(TPC1, KTC-1, BCPAP, HTORI-3) |
| Expression Pattern | up-regulated |
| Function Description | The study revealed that long non-coding RNA LINC00673 was significantly upregulated in thyroid cancer tissues compared with paired adjacent non-tumor tissues using RT-qPCR and that high expression of LINC00673 is was associated with larger tumor size and lymph node metastasis in the validated cohort. Knockdown of LINC00673 inhibited cell proliferation and metastasis, the results showed that LINC00673 may influence EMT and the expression of Kruppel-like factor 2 (KLF2). This finding indicated that low KLF-2 expression was associated with an unfavorable prognosis in patients with thyroid carcinoma. |
| Pubmed ID | 30106140 |
| Year | 2018 |
| Title | lncRNA LINC00673 induces proliferation, metastasis and epithelial-mesenchymal transition in thyroid carcinoma via Kruppel-like factor 2. |
External Links
| Links for LINC00673 | GenBank HGNC NONCODE |
| Links for thyroid cancer | OMIM COSMIC |