Basic Information
| LncRNA/CircRNA Name | LINC00673 |
| Synonyms | NA |
| Region | GRCh38_1:29554-31109 |
| Ensemble | |
| Refseq | NR_036488 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qRT-PCR , Luciferase reporter assay etc. |
| Sample | gastric cancer and paired adjacent normal tissues ,BGC-803 cell line |
| Expression Pattern | down-regulated |
| Function Description | We found rs11655237 significantly increased susceptibility of GC in the Chinese population , and a significant interaction was found between rs11655237 and Helicobacter pylori infection.Expression of LINC00673 was significantly higher in adjacent normal tissues than in paired cancer tissues and significantly lower in the cancer or paired adjacent normal tissues of GC patients with rs11655237 allele A than in those with rs11655237 allele G.Mechanism exploration found that, the construct with the rs11655237[A] allele had significantly reduced luciferase activity in the presence of miR-1231, and this effect could be completely rescued when miR-1231 inhibitor was present. |
| Pubmed ID | 31118802 |
| Year | 2019 |
| Title | Functional variants of lncRNA LINC00673 and gastric cancer susceptibility: a case-control study in a Chinese population |
External Links
| Links for LINC00673 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |