Basic Information
| LncRNA/CircRNA Name | LINC00673 |
| Synonyms | NA |
| Region | GRCh38_1:29554-31109 |
| Ensemble | |
| Refseq | NR_036488 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | Paclitaxel | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | RT-qPCR, Western blot analysis, Dual luciferase reporter gene assay, RIP |
| Sample | Prostate cancer cells (PC3, LNCap and DU145), paclitaxel-resistant cell line (DU145/pr) and normal prostate epithelial cell line (RWPE-1),prostate cancer tissues |
| Expression Pattern | up-regulated |
| Function Description | LINC00673 was highly expressed, while KLF4 was poorly expressed in prostate cancer tissues. Additionally, LINC00673 could bind to KLF4 gene promoter region and recruit methyltransferase to the KLF4 gene promoter region. Moreover, LINC00673 silencing was demonstrated to reduce methylation of the KLF4 gene promoter to elevate the expression of KLF4, thus suppressing the proliferation and drug resistance of prostate cancer cells. |
| Pubmed ID | 31881124 |
| Year | 2020 |
| Title | Long Non-Coding RNA LINC00673 Silencing Inhibits Proliferation and Drug Resistance of Prostate Cancer Cells via Decreasing KLF4 Promoter Methylation |
External Links
| Links for LINC00673 | GenBank HGNC NONCODE |
| Links for prostate cancer | OMIM COSMIC |