Basic Information
| LncRNA/CircRNA Name | LINC00668 |
| Synonyms | NA |
| Region | GRCh38_18:6919496-6929966 |
| Ensemble | ENSG00000265933 |
| Refseq | NR_034100 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot, RIP, Luciferase reporter assay etc. |
| Sample | gastric cancer tissues, cell lines (SGC-7901, BGC-823, MGC-803) |
| Expression Pattern | up-regulated |
| Function Description | By utilizing publicly available lncRNAs expression profiling data and integrating analyses, we screened out LINC00668, whose expression is significantly increased and correlated with outcomes in gastric cancer (GC). Further experiments revealed that LINC00668 knockdown significantly repressed proliferation, both in vitro and in vivo. Mechanistic investigations showed that LINC00668 was a direct transcriptional target of E2F transcription factor 1 (E2F1). We further demonstrated that LINC00668 was associated with PRC2 and that this association was required for epigenetic repression of cyclin-dependent protein kinase inhibitors (CKIs), including p15, p16, p21, p27 and p57, thus contributing to the regulation of the gastric cancer cell cycle. |
| Pubmed ID | 27036039 |
| Year | 2015 |
| Title | E2F1-induced upregulation of long noncoding RNA LINC00668 predicts a poor prognosis of gastric cancer and promotes cell proliferation through epigenetically silencing of CKIs |
External Links
| Links for LINC00668 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |