Basic Information
| LncRNA/CircRNA Name | LINC00668 |
| Synonyms | NA |
| Region | GRCh38_18:6919496-6929966 |
| Ensemble | ENSG00000265933 |
| Refseq | NR_034100 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qRT-PCR, in vitro knockdown , Western blot, Chromatin immunoprecipitation (ChIP) assays, RIP etc. |
| Sample | lung cancer and paired normal tissues ,lung cancer cell lines (H1975, H1299, PC 9, SPCA1) |
| Expression Pattern | up-regulated |
| Function Description | Clinical investigation demonstrated that high expression level of LINC00668 was associated with advanced TNM stage, histological grade and lymph node metastasis. Moreover, multivariate analysis confirmed LINC00668 expression level to be an independent prognostic indicator for overall survival of NSCLC patients. Functional assays indicated that knockdown of LINC00668 suppressed NSCLC cells proliferation, migration and invasion, and promoted apoptosis. Mechanistic studies indicated that LINC00668 is a direct target of miR-193a, leading to down-regulation in the expression of its target gene KLF7. |
| Pubmed ID | 31150989 |
| Year | 2019 |
| Title | STAT3-induced Long Noncoding RNA LINC00668 Promotes Migration and Invasion of Non-Small Cell Lung Cancer via the miR-193a/KLF7 Axis |
External Links
| Links for LINC00668 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |