Basic Information
| LncRNA/CircRNA Name | LINC00665 |
| Synonyms | NA |
| Region | GRCh38_19:36313067-36331718 |
| Ensemble | ENSG00000232677 |
| Refseq | NR_038278 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qRT-PCR, Western blot, Luciferase reporter assay |
| Sample | GC tissue specimens,GC cells (AGS, SGC-7901, HGC27, MGC-803, MKN-45, and BGC-823) and normal gastric epithelial cells (GES-1) |
| Expression Pattern | up-regulated |
| Function Description | LINC00665 expression was significantly elevated in GC tissues and cell lines. High LINC00665 expression was associated with TNM stage, histological grade, and poor prognosis of GC patients. Function assays showed that LINC00665 suppression significantly reduced GC cells viability and invasion ability in vitro. Mechanistic analysis showed that LINC00665 might serve as a ceRNA for miR-149-3p to regulate the expression of RNF2. |
| Pubmed ID | 31695413 |
| Year | 2019 |
| Title | Long Non-Coding RNA LINC00665 Gastric Cancer Tumorigenesis by Regulation miR-149-3p/RNF2 Axis |
External Links
| Links for LINC00665 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |