Basic Information
| LncRNA/CircRNA Name | LINC00662 |
| Synonyms | NA |
| Region | GRCh38_19:27684580-27793940 |
| Ensemble | ENSG00000261824 |
| Refseq | NR_027301 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | oral squamous cell carcinoma |
| ICD-0-3 | C06.9 |
| Methods | qPCR, Western blot, in vitro knockdown, etc. |
| Sample | TSCC tissues, Human immortal oral epithelial cells (HIOEC),OSCC cell lines CGHNC9, ISG15, SCC9, and SCC25 |
| Expression Pattern | up-regulated |
| Function Description | the expression of LINC00662 was significantly increased in OSCC tissues, and a higher expression of LINC00662 was detected in larger tumor size, higher stage tumors and with lymph node metastasis. Moreover, overexpression of LINC00662 induced OSCC cell proliferation, increased migration and invasion abilities, and suppressed cell apoptosis. Knockdown of LINC00662 decreased the proliferation, migration, and invasion abilities of OSCC cell, and induced apoptosis. Furthermore, LINC00662 regulated the Wnt/?-catenin pathway. Conclusion: Our data indicate that LINC00662 may represent a novel indicator of OSCC and may be a potential therapeutic target for diagnosis and therapy. |
| Pubmed ID | 30705593 |
| Year | 2019 |
| Title | Long non-coding RNA LINC00662 promotes proliferation and migration in oral squamous cell carcinoma. |
External Links
| Links for LINC00662 | GenBank HGNC NONCODE |
| Links for oral squamous cell carcinoma | OMIM COSMIC |