Basic Information
| LncRNA/CircRNA Name | LINC00662 |
| Synonyms | NA |
| Region | GRCh38_19:27684580-27793940 |
| Ensemble | ENSG00000261824 |
| Refseq | NR_027301 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | qRT-PCR , Luciferase reporter assay , in vitro knockdown etc. |
| Sample | prostate cancer tissues and adjacent normal tissues ,WPMY-1 cells (normal prostate epithelial cells) ,prostate cancer cells (DU145, 22RV1, PC-3, and LNCaP) |
| Expression Pattern | up-regulated |
| Function Description | LINC00662 was significantly upregulated in PCa tissues and cell lines compared with adjacent normal tissue and a normal prostate epithelial cell line.Higher expression of LINC00662 was positively associated with distant metastasis and shorter overall survival.tissue LINC00662 expression was confirmed to be an independent prognostic factor for PCa.Furthermore, LINC00662 silencing inhibited the proliferation, migration, and invasion of PC-3 and LNCaP cells, and promoted apoptosis in vitro.LINC00662 could function as a sponge of miR-34a in PCa cells. Also, the results of RT-PCR showed that knockdown of LINC00662 suppressed the expression levels of miR-34a. |
| Pubmed ID | 31114993 |
| Year | 2019 |
| Title | Long Noncoding RNA LINC00662 Functions as miRNA Sponge to Promote the Prostate Cancer Tumorigenesis Through Targeting miR-34a |
External Links
| Links for LINC00662 | GenBank HGNC NONCODE |
| Links for prostate cancer | OMIM COSMIC |