Basic Information
| LncRNA/CircRNA Name | LINC00662 |
| Synonyms | NA |
| Region | GRCh38_19:27684580-27793940 |
| Ensemble | ENSG00000261824 |
| Refseq | NR_027301 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colon cancer |
| ICD-0-3 | C18 |
| Methods | luciferase reporter assay, Western-blot analysis, qRT-PCR |
| Sample | Cancer tissue,colon epithelial cells (NCM460) and colon cancer cell lines (HCT116, HCT8, HCT29, LOVO, SW480, CT26 and LS174T) |
| Expression Pattern | up-regulated |
| Function Description | LINC00662 was up-regulation in colon cancer tissues and cell lines. Univariate Cox regression analysis showed that the LINC00662 expression level was related to the poor prognosis.LINC00662 overexpression promoted cell proliferation, invasion and migration, and inhibited cell apoptosis in colon cancer. In vivo xenograft studies in nude mice manifested that LINC00662 overexpression prominently accelerate tumor growth. There was an opposite reaction in the biological functions of colon cells and tumor growth between LINC00662 overexpression and LINC00662 inhibition in vitro and in vivo. |
| Pubmed ID | 31900207 |
| Year | 2020 |
| Title | LncRNA LINC00662 Promotes Colon Cancer Tumor Growth and Metastasis by Competitively Binding With miR-340-5p to Regulate CLDN8/IL22 Co-Expression and Activating ERK Signaling Pathway |
External Links
| Links for LINC00662 | GenBank HGNC NONCODE |
| Links for colon cancer | OMIM COSMIC |