Basic Information
| LncRNA/CircRNA Name | LINC00659 |
| Synonyms | NA |
| Region | GRCh38_20:62774128-62775412 |
| Ensemble | ENSG00000228705 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | Microarray, qPCR etc. |
| Sample | cell lines (DLD-1, colo205, colo320DM, LS174T, HCT116, SW620, LOVO,HT29), colon cancer tissue |
| Expression Pattern | up-regulated |
| Function Description | Linc00659 expression knockdown could significantly suppress colon cancer cell growth by impairing cell cycle progression.Linc00659 expression knockdown could accelerate cell apoptosis in colon cancer cells treated with chemotherapy drugs.Silencing of Linc00659 expression leads to cell growth inhibition and induced apoptosis,possibly by suppressing PI3K-AKT signaling in colon cancer.Linc00659 is a novel oncogenic lncRNA involved in colon cancer cell growth by modulating the cell cycle. |
| Pubmed ID | 29523145 |
| Year | 2018 |
| Title | Linc00659, a long noncoding RNA, acts as novel oncogene in regulating cancer cell growth in colorectal cancer. |
External Links
| Links for LINC00659 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |