Basic Information
| LncRNA/CircRNA Name | LINC00657 |
| Synonyms | NORAD, LINC00657, ASHGA5P032173 |
| Region | GRCh38_20:36045618-36050960 |
| Ensemble | ENSG00000260032 |
| Refseq | NR_027451 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, in vitro knockdown, MTT assay etc. |
| Sample | cell lines (MCF-7, MDA-MB-231, HMLE) |
| Expression Pattern | up-regulated |
| Function Description | We found that LINC00657 was upregulated in breast cancer cell lines MCF-7 and MDA-MB-231 cells as compared to non-malignant HMLE cells. LINC00657 knockout significantly suppresses tumor cell growth and proliferation, suggesting that it plays an oncogenic role. |
| Pubmed ID | 26942882 |
| Year | 2016 |
| Title | Long non-coding RNAs as prognostic markers in human breast cancer. |
External Links
| Links for LINC00657 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |