Basic Information
| LncRNA/CircRNA Name | LINC00657 |
| Synonyms | NORAD, LINC00657, ASHGA5P032173 |
| Region | GRCh38_20:36045618-36050960 |
| Ensemble | ENSG00000260032 |
| Refseq | NR_027451 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Western blot etc. |
| Sample | cell lines (HepG2, Huh7, Hep3B, Bel-7402, SMMC-7721, HCCM3) |
| Expression Pattern | down-regulated |
| Function Description | The expression level of LINC00657 was downregulated in HCC tissues and HCC cell lines.Moreover,we illustrated the role of LINC00657 in suppressing the growth, invasion, migration of HCC in vitro.In addition, we found that LINC00657 can act as a ceRNA for PTEN mRNA through miR-106a-5p.Finally, we confirmed the role of LINC00657 in vivo.These results deepen our understanding of the role of LINC00657 in HCC. |
| Pubmed ID | 28919047 |
| Year | 2017 |
| Title | Long non-coding RNA 657 suppresses hepatocellular carcinoma cell growth by acting as a molecular sponge of miR-106a-5p to regulate PTEN expression |
External Links
| Links for LINC00657 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |