Basic Information
| LncRNA/CircRNA Name | LINC00641 |
| Synonyms | NA |
| Region | GRCh38_14:21200079-21206900 |
| Ensemble | ENSG00000258441 |
| Refseq | NR_038970 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, Luciferase reporter assay, etc. |
| Sample | BC tissues, BC cell lines (BCAP-37, MDA-MB-453, UACC-812, MCF-7, and MDA-MB-231), normal breast epithelial cell line MCF-10A |
| Expression Pattern | down-regulated |
| Function Description | LINC00641 expression level was decreased in BC tissues. LINC00641 expression level was negatively related to tumor size, lymph node metastasis, as well as clinical stage. LINC00641 overexpression inhibited cell proliferation, migration, and invasion but stimulated apoptosis in BC cells. LINC00641 overexpression also remarkably reduced BC growth and metastasis in vivo. LINC00641 acts as a competitive endogenous RNA to sponge miR 194 5p. miR 194 5p level was higher in BC tissues and cells compared with normal adjacent tissues and normal breast epithelial cell. miR 194 5p expression was negatively correlated with LINC00641 expression in BC tissues. miR 194 5p overexpression reversed the effects of LINC00641 on cell proliferation, cycle, apoptosis, migration, as well as invasion. |
| Pubmed ID | 31490021 |
| Year | 2019 |
| Title | Long intergenic noncoding RNA 00641 inhibits breast cancer cell proliferation, migration, and invasion by sponging miR-194-5p |
External Links
| Links for LINC00641 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |