Basic Information
| LncRNA/CircRNA Name | LINC00641 |
| Synonyms | NA |
| Region | GRCh38_14:21200079-21206900 |
| Ensemble | ENSG00000258441 |
| Refseq | NR_038970 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | bladder cancer |
| ICD-0-3 | C67 |
| Methods | qPCR, Luciferase reporter assay |
| Sample | bladder cancer tissues, cell lines (T24, SW780, J82, SV-HUC-1) |
| Expression Pattern | down-regulated |
| Function Description | We found that LINC00641 expression was significantly down-regulated in bladder cancer tissues. Down-regulation of LINC00641 in patients with bladder cancer predicts poor prognosis. Gain-of-function assays indicated that LINC00641 up-regulation markedly inhibited the proliferation, migration and invasion of bladder cancer cells. LINC00641 was demonstrated to interact with miR-197-3p. |
| Pubmed ID | 30060954 |
| Year | 2018 |
| Title | LncRNA LINC00641 Predicts Prognosis and Inhibits Bladder Cancer Progression Through miR-197-3p/KLF10/PTEN/PI3K/AKT Cascade. |
External Links
| Links for LINC00641 | GenBank HGNC NONCODE |
| Links for bladder cancer | OMIM COSMIC |